Scientific Info – Photobiomodulation – Health & Development Coach

Validated Scientific Accredited Data

There is plenty of compelling data and evidence available

that backs the benefits of Photobiomodulation –

Light Therapy Technology.

Here are just a few articles to follow up.

However you can also just search

“photobiomodulation” “pubmed” and any ailment you would like links to.

Lots of information to show credibility of this amazing technology.

The WellBeam Light Spectrum product range used at Heal Yourself Studio contains 660nm Red, 470nm Blue and/or 850nm Near-Infrared LEDs.

They are lighting devices used on the body, embracing the same specifications found in many of the below studies.

Nogier frequencies

The naked eye can see up to 50 Hz.
Different devices/equipment contains varying abilities to produce the below, extremely fast pulse rates.

The majority of research listed will contain at least one of the below pulse rates.

Nogier Frequencies: Auricular Acupuncture

NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea (marquette.edu)

NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea
Extract:
NASA LEDs stimulate the basic energy processes in the mitochondria (energy compartments) of each cell, particularly when near-infrared light is used to activate the colour sensitive chemicals (chromophores, cytochrome systems) inside. Optimal LED wavelengths include 680, 730 and 880 nm and our laboratory has improved the healing of wounds in laboratory animals by using both NASA LED light and hyperbaric oxygen. Furthermore, DNA synthesis in fibroblasts and muscle cells has been quintupled using NASA LED light alone, in a single application combining 680, 730 and 880 nm each at 4 Joules per centimetre squared

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148276/

Effects of low-power light therapy on wound healing: LASER x LED*
Extract:
The biological effects promoted were reduction of inflammatory cells, increased proliferation of fibroblasts, stimulation of collagen synthesis, angiogenesis inducement and granulation tissue formation. It was noted in a study that the dose of 4 J/cm2 was more effective than 8 J/cm2 .14 Furthermore, doses of 10 and 16 J/cm2 promoted inhibitory effects.20,25,29,34

http://www.ncbi.nlm.nih.gov/pubmed/16706690

Clinical and experimental applications of NIR-LED photobiomodulation
Extract:
Positive effects of NIR-light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production. Various in vitro and in vivo models of mitochondrial dysfunction were treated with a variety of wavelengths of NIR-LED light.

http://www.ncbi.nlm.nih.gov/pubmed/11776448

Effect of NASA light-emitting diode irradiation on wound healing
Extract:
Conclusion: We believe that the use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/illness level of activity. This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2539004/
Infrared therapy for chronic low back pain: A randomized, controlled trial.
Extract:
Recently, infrared (IR) therapy has been developed, which has shown improved wound healing (7–9), relief of arthritic knee pain (10), increased endorphin levels (11) and bioactivation of neuromodulators (11–13).

http://www.ncbi.nlm.nih.gov/pubmed/16641531
Light-emitting diode phototherapy at 630 +/- 3 nm increases local levels of skin-homing T-cells in human subjects
Extract:
Results: Transmission electron microscopy revealed mild fibroplastic changes in fibroblasts, with no acute inflammatory changes throughout the treatment session. Qualitative PCR showed the presence of both Th-1 and Th-2 T-cells, and quantitative PCR showed an increase in the numbers of both types of skin-homing T-cells, much more so for Th-2 than for Th-1.
Conclusions: Visible red LED irradiation appears to activate the skin-homing immune system.

http://www.ncbi.nlm.nih.gov/pubmed/15895289
Evidence of changes in sural nerve conduction mediated by light emitting diode irradiation
Extract:
Based on these results, it can be concluded that LED irradiation, applied to intact skin at the described irradiation parameters, produces an immediate and localized effect upon conduction characteristics in underlying nerves. Therefore, the outcome of this in vivo experiment yields a potential explanation for pain relief induced by LED.

http://www.photobiology.info/Hamblin.html
Mechanisms of Low Level Light Therapy
Extract
The use of low levels of visible or near-infrared (NIR) light for reducing pain, inflammation and edema, promoting healing of wounds, deeper tissues and nerves, and preventing tissue damage has been known for almost forty years since the invention of lasers.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065857/
Role of Low-Level Laser Therapy in Neurorehabilitation
Extract
In recent years, LLLT has become an increasingly mainstream modality, especially in the areas of physical medicine and rehabilitation. At first used mainly for wound healing and pain relief, the medical applications of LLLT have broadened to include diseases such as stroke, myocardial infarction, and degenerative or traumatic brain disorders. This review will cover the mechanisms of LLLT that operate both on a cellular and a tissue level.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113823/
An investigation into the depth of penetration of low level laser therapy through the equine tendon in vivo
Extract
Low level laser therapy (LLLT) is frequently used in the treatment of wounds, soft tissue injury and in pain management. The exact penetration depth of LLLT in human tissue remains unspecified. Similar uncertainty regarding penetration depth arises in treating animals. This study was designed to test the hypothesis that transmission of LLLT in horses is increased by clipping the hair and/or by cleaning the area to be treated with alcohol, but is unaffected by coat colour.

https://www.ncbi.nlm.nih.gov/pubmed/6727856
Use of laser light to treat certain lesions in standardbreds
Extract
Of 8 horses treated for plantar desmitis, 87.5% had similar or faster final and last-quarter times, and raced in similar or higher classes after treatment. Of 30 horses treated for pharyngeal lymphoid hyperplasia, 80% had similar or faster final race times, 90% had similar or faster last-quarter times, and 70% raced in similar or higher classes after treatment.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799034/
Is light-emitting diode phototherapy (LED-LLLT) really effective?
Extract:
Conclusions: Provided an LED phototherapy system has the correct wavelength for the target cells, delivers an appropriate power density and an adequate energy density, then it will be at least partly, if not significantly, effective. The use of LED-LLLT as an adjunct to conventional surgical or nonsurgical indications is an even more exciting prospect. LED-LLLT is here to stay.

https://ntrs.nasa.gov/search.jsp?R=20030001599
The Use of NASA Light-Emitting Diode Near-Infrared Technology for Biostimulation
Extract:
An LED blanket device may be used for the prevention of bone and muscle atrophy in astronauts. The depth of near-infrared light penetration into human tissue has been measured spectroscopically.

://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796659/
Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety
Extract:
This small feasibility study suggests that NIR-PBM may have utility for the treatment of depression and other psychiatric disorders and that double blind randomized placebo-controlled trials are indicated.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627142/
Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study
Extract:
This is the first report of high-powered NILT showing efficacy for depression. Multi-Watt NILT showed far greater efficacy and persistent benefit compared to low-power

https://www.ncbi.nlm.nih.gov/pubmed/27857496
Effect of near-infrared light on in vitro cellular ATP production of osteoblasts and fibroblasts and on fracture healing with intramedullary fixation.
Extract:
Conclusion: The study demonstrated an immediate increase in ATP production in vitro and an initial acceleration of callus formation in the fracture healing process, in the presence of NIR

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/
Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures
Extract:
Conclusions: A growing body of clinical evidence is showing that applying 830 nm LED-LLLT as soon as possible post-procedure, both invasive and noninvasive, successfully hastens the resolution of sequelae associated with patient downtime in addition to significantly speeding up frank wound healing. This article reviews that evidence, and attempts to show that 830 nm LED-LLLT delivers swift resolution of postoperative sequelae, minimizes downtime and enhances patient satisfaction

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651919/
Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways
Extract:
these findings provide the first evidence that FIR confers a real and significant benefit on the preconditioning of BMSCs, and might lead to novel strategies for improving BMSC therapy for cardiac ischemia.

https://www.nasa.gov/topics/nasalife/features/heals.html
NASA Light Technology Successfully Reduces Cancer Patients Painful Side Effects from Radiation and Chemotherapy
Extract:
A NASA technology originally developed for plant growth experiments on space shuttle missions has successfully reduced the painful side effects resulting from chemotherapy and radiation treatment in bone marrow and stem cell transplant patients.

https://www.research.va.gov/currents/spring2015/spring2015-7.cfm
US Department of Veteran Affairs – Research & Development – Can Light Therapy help the brain?
Extract:
Neuropsychological testing before the therapy and at several points thereafter showed gains in areas such as executive function, verbal learning, and memory. The study volunteers also reported better sleep and fewer PTSD symptoms.

NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea
Extract:
NASA LEDs stimulate the basic energy processes in the mitochondria (energy compartments) of each cell, particularly when near-infrared light is used to activate the colour sensitive chemicals (chromophores, cytochrome systems) inside. Optimal LED wavelengths include 680, 730 and 880 nm and our laboratory has improved the healing of wounds in laboratory animals by using both NASA LED light and hyperbaric oxygen. Furthermore, DNA synthesis in fibroblasts and muscle cells has been quintupled using NASA LED light alone, in a single application combining 680, 730 and 880 nm each at 4 Joules per centimetre squared

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148276/

http://www.ncbi.nlm.nih.gov/pubmed/16706690
Clinical and experimental applications of NIR-LED photobiomodulation
Extract:
Positive effects of NIR-light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production. Various in vitro and in vivo models of mitochondrial dysfunction were treated with a variety of wavelengths of NIR-LED light.

http://www.ncbi.nlm.nih.gov/pubmed/11776448
Effect of NASA light-emitting diode irradiation on wound healing
Extract:
Conclusion: We believe that the use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/illness level of activity. This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065857/

Role of Low-Level Laser Therapy in Neurorehabilitation
Extract
In recent years, LLLT has become an increasingly mainstream modality, especially in the areas of physical medicine and rehabilitation. At first used mainly for wound healing and pain relief, the medical applications of LLLT have broadened to include diseases such as stroke, myocardial infarction, and degenerative or traumatic brain disorders. This review will cover the mechanisms of LLLT that operate both on a cellular and a tissue level.

BLUE LIGHT THERAPY RESEARCH

Blue Light in Dermatology – PMC (nih.gov)

Blue Light in Dermatology
Extract: Phototherapy is an important method of dermatological treatments. The main factors responsible for biological changes induced by blue light are light parameters. Developing accurate protocols is crucial, as clinical effects are not only related to the duration of the treatment, but also to the dose and intensity of irradiations.

Clinical Efficacy of Self-applied Blue Light Therapy for Mild-to-Moderate Facial Acne – PMC (nih.gov)
Clinical Efficacy of Self-applied Blue Light Therapy for Mild-to-Moderate Facial Acne
Subjects evaluated self administration of the blue light treatment according to the device’s labeling as being safe and effective. The study showed that daily self treatment using the device for mild-to-moderate inflammatory acne reduced the number of acne lesions significantly. Moreover, the study demonstrated a significant improvement of the subjects’ skin conditions. Subjects included in the study were able to safely and effectively administer self treatment with the device and felt confident doing so.

Light as a potential treatment for pandemic coronavirus infections: A perspective – ScienceDirect
Light as a potential treatment for pandemic coronavirus infections
Extract: the resulting 93% increase in decay constant and the concomitant 92.3% decline in half-life due to light is impressive. This recent development buttresses the suggestion that blue light, in particular, pulsed blue light, which recent reports have shown to be 40 to 100 times more potent than the commonly available continuous wave blue light [[34], [35], [36]], has great potential to inactivate COVID-19 and other coronaviruses, in addition to suppressing related opportunistic bacterial infections.

Light As Medicine? | wisconsinacademy.org
Light as Medicine?
Extract:: Enwemeka notes that to achieve complete destruction of bacterial colonies with blue light, the treatment must be repeated. But given its relative ease of application, blue light therapy holds tremendous promise as an alternative to full-spectrum antibiotics, many of which are decreasing in efficacy. Humans are exposed to so many antibiotics—through food sources and careless use of prescribed medications—that bacterial resistance is now rising much faster than the rate of new drug discovery.
In contrast to far-red and NIR light which stimulate the body’s repair of injured cells, blue light improves wound healing by killing the bacteria that cause wound infections.
UWM’s Enwemeka is a pioneer in the use of LED blue light to clear infections. In a 2007 study supported by Dynatronics Corporation, Enwemeka discovered that some wavelengths of blue light, especially those in the 405–470 nm wavelength, kill bacteria so effectively that the process even works on MRSA, the antibiotic-resistant “superbug” form of Staphylococcus aureus.

(PDF) Light Therapy for Seasonal Affective Disorder with Blue Narrow-Band Light-Emitting Diodes (LEDs) (researchgate.net)
Light Therapy for SAD
Extract:: While light has proven an effective treatment for Seasonal Affective Disorder (SAD), an optimal wavelength combination has not been determined. Short wavelength light (blue) has demonstrated potency as a stimulus for acute melatonin suppression and circadian phase shifting.

Aspects of Antiviral Strategies Based on Different Phototherapy Approaches: Hit by the Light – PMC (nih.gov)
Aspects of Antiviral Strategies
Extract: Conclusions
Light-based therapeutic approaches are characterized by the ability to focus the beam of light onto the lesion or the part of the body that requires treatment. This has been often taken advantage of in the treatment of cancer, where the selectivity provided by the spatial confinement of illumination reduces the damage to surrounding normal tissue. However, light-based treatments can also be useful in the case of localized infections, and for sterilizing various products, such as blood products, medical devices, and foodstuffs. Every known class of pathogen can be inactivated by the appropriate PT approach, including bacteria, fungi, viruses, protozoa, parasites, and even prions. For viral infections, the reactive oxygen species produced by PT can either damage the virus structure itself and/or the host cells that are infected by the virus. Enveloped viruses which contain protein and lipids in the envelope are more easily oxidized by ROS compared to nonenveloped viruses. It is still uncertain to what extent PT approaches may be useful in systemic viral infections, but PDT has been shown to activate the host immune response in cancer treatment, and this may also apply to trigger the immune response against viruses. Antiviral phototherapy and photoacoustics, including photoacoustic molecular imaging, are two very promising approaches to fight against viral infections. Despite the potential of the photoacoustic approach, the data in the literature is still scarce. Antiviral PAT, as one of the latest phototherapy techniques, still requires more development, in order to become a precise and effective treatment. Nevertheless, photoacoustic antiviral treatment could allow the precise destruction of virus-infected cells, and minimize the damage to the surrounding normal tissue and cells.

Can biowarfare agents be defeated with light? – PMC (nih.gov)Can biowarfare agents be defeated with light? – PMC (nih.gov)
Can biowarfare agents be defeated with light?
Extract Conclusion: Recent studies have highlighted the diversity of applications of light-mediated technology against pathogens of all known classes. Wavelengths from the short-UV to the near-infrared (either alone or combined with PS) can be used to kill or inactivate gram-positive and gram-negative bacteria, fungi, endospores, parasites, viruses, and even protein toxins. The mechanisms of action depend on the different microbial types and the wavelength and presence or not of a PS. The two broad target classes are nucleic acids for UVC and PUVA and oxidizable proteins for photocatalysis, PDT, and blue light. The broad occurrence of these biological targets in bioweapons agents means that the light-mediated technology is highly likely to be very broad-spectrum, thus avoiding the need to know the identity of the particular agent in any mass biological attack, and also suggests that the development of resistance to light-mediated inactivation is likely to non-existent. Furthermore, light is non-polluting and environmentally friendly, and even if PS need to be used, these compounds are likely to be photodegraded rapidly when the bio-threat has been neutralized thus leaving no lasting pollution. The use of light-based technology to prevent and treat actual infections suggests that they may be useful to decontaminate humans that have already received exposure to biological agents, without causing undue harm to host tissue. Lastly light-based inactivation may be particularly suitable to form vaccines as they kill pathogens while preserving their antigenicity.

Directory: National Library of Medicine

Blue Light Therapy – PMC – NCBI (nih.gov)
Phototherapy and Optical Waveguides for the Treatment of Infection
Extract: phototherapy appears to be a promising approach for the local infection treatment and prophylaxis due to its broad-spectrum antimicrobial and antiviral activities, low invasiveness, minimal systemic side effects, and no evidence of inducing treatment resistance (except direct UV therapy and PTT).

Blue Light Therapy viral infection – PMC – NCBI (nih.gov)
New Insights Into Blue Light Phototherapy in Experimental Trypanosoma cruzi Infection
Extract: Blue light treatment reduced the quantification of distinct (Y and CL) strains of T. cruzi and reduced blood and intracellular forms of the parasite in mammalian hosts. These data support the importance of an alternative and/or complementary therapy against T. cruzi and instigate further investigations on the underlying mechanism and whether long-term phototherapy mitigates myocarditis diagnosed in experimental and human infections.

Can biowarfare agents be defeated with light? – PMC (nih.gov)
Can biowarfare agents be defeated with light?
Extract: Recent studies have highlighted the diversity of applications of light-mediated technology against pathogens of all known classes. Wavelengths from the short-UV to the near-infrared (either alone or combined with PS) can be used to kill or inactivate gram-positive and gram-negative bacteria, fungi, endospores, parasites, viruses, and even protein toxins.

Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond – PMC (nih.gov
Light based anti-infectives
Extract: Many microbial cells are highly sensitive to killing by blue light (400–470 nm) due to accumulation of naturally occurring photosensitizers such as porphyrins and flavins. Near infrared light has also been shown to have antimicrobial effects against certain species. Clinical applications of these technologies include skin, dental, wound, stomach, nasal, toenail and other infections which are amenable to effective light delivery.

While Blue Light has many health benefits, it is not healthy for eyes, especially in such a concentrated form. Goggles must be worn (provided) when using anywhere when the illumination is in direct line of sight.

RED LIGHT THERAPY RESEARCH

Photodynamic and photobiological effects of light-emitting diode (LED) therapy in dermatological disease: an update – PMC (nih.gov)
Conclusion: PDT is an effective form of treatment for an increasing number of human conditions, ranging from cancer to several skin conditions. Benefit deriving from the use of light is known since ancient time, but only in the last decades of twentieth century, we witnessed the rapid expansion of knowledge and techniques. Recent improvements of the therapy are related especially to photosensitizer’s development and delivery systems. Nowadays, the use of LED-based devices represents the emerging and safest tool for the treatment of many conditions such as skin inflammatory conditions, aging, and disorders linked to hair growth. Although the use of LED in the treatment of hair disorders has now entered common practice, better controlled studies are still needed to corroborate its efficacy.

Review of Literature on Low-level Laser Therapy Benefits for Nonpharmacological Pain Control in Chronic Pain and Osteoarthritis – PubMed (nih.gov)
Conclusion: Based on current research, the utilization of LLLT for pain management and osteoarthritic conditions may be a complementary strategy used in clinical practice to provide symptom management for patients suffering from osteoarthritis and chronic pain.

A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase – PMC (nih.gov)
Conclusion: RLT and ELT are large-area and full-body treatment modalities for skin rejuvenation and improvements in skin feeling and skin complexion. The application of RLT and ELT provides a safe, non-ablative, non-thermal, atraumatic photobiomodulation treatment of skin tissue with high patient satisfaction rates. RLT and ELT can extend the spectrum of anti-aging treatment options available to patients looking for mild and pleasant light-only skin rejuvenation

Photobiomodulation: The Clinical Applications of Low-Level Light Therapy

Photobiomodulation: The Clinical Applications of Low-Level Light Therapy – PubMed (nih.gov)
Results: A reasonable body of clinical trial evidence exists to support the role of low-energy red/near-infrared light as a safe and effective method of skin rejuvenation, treatment of acne vulgaris and alopecia, and, especially, body contouring. Methodologic flaws, small patient cohorts, and industry funding mean there is ample scope to improve the quality of evidence. It remains unclear if light-emitting diode sources induce physiologic effects of compararable nature and magnitude to those of the laser-based systems used in most of the higher-quality studies.

Efficacy of the LED Red Light Therapy in the Treatment of Temporomandibular Disorders: Double Blind Randomized Controlled Trial

Efficacy of the LED Red Light Therapy in the Treatment of Temporomandibular Disorders: Double Blind Randomized Controlled Trial – PubMed (nih.gov)
Results: The changes in the pain value and number of the tender muscles in both groups were highly significant, only placebo group less but with no significant differences.
Conclusions: This study showed that red LED therapy could be useful in improving patient’s symptoms regarding pain, clicking, and number of tender muscles. In addition, this study showed the importance of the psychological part of treatment of those patients. This trial is registered with TCTR20190406002.

Effect of Repeated Low-Level Red-Light Therapy for Myopia Control in Children

Effect of Repeated Low-Level Red-Light Therapy for Myopia Control in Children – Ophthalmology (aaojournal.org)
Extract: In conclusion, among Chinese children 8 to 13 years of age with myopia, RLRL therapy is an effective new alternative treatment for myopia control with good user acceptability and no documented functional or structural damage; however, further research with double-masking and placebo control is needed to understand its long-term efficacy and safety, rebound effects, optimal treatment strategies (wavelength, power, duration, and frequency of treatment), and potential underlying mechanisms.

Low-level light therapy of the eye and brain
Low-level light therapy of the eye and brain – PubMed (nih.gov)
Extract: Recent research is reviewed that supports LLLT potential benefits in retinal disease, stroke, neurotrauma, neurodegeneration, and memory and mood disorders. Since mitochondrial dysfunction plays a key role in neurodegeneration, LLLT has potential significant applications against retinal and brain damage by counteracting the consequences of mitochondrial failure. Upon transcranial delivery in vivo, LLLT induces brain metabolic and antioxidant beneficial effects, as measured by increases in cytochrome oxidase and superoxide dismutase activities. Increases in cerebral blood flow and cognitive functions induced by LLLT have also been observed in humans. Importantly, LLLT given at energy densities that exert beneficial effects does not induce adverse effects. This highlights the value of LLLT as a novel paradigm to treat visual, neurological, and psychological conditions, and supports that neuronal energy metabolism could constitute a major target for neurotherapeutics of the eye and brain.

A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation
A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation – PubMed (nih.gov)
Results: Key profilometry results Sq, Sa, Sp and St showed significant differences at week 12 follow-up; 52% of subjects showed a 25%-50% improvement in photoaging scores by week 12; 81% of subjects reported a significant improvement in periorbital wrinkles on completion of follow-up.
Conclusion: Omnilux combination red and near infrared LED therapy represents an effective and acceptable method of photo rejuvenation. Further study to optimize the parameters of treatment is required.

Declining eyesight improved by looking at deep red light
Declining eyesight improved by looking at deep red light | UCL News – UCL – University College London
Extract: Professor Jeffery said: “Our study shows that it is possible to significantly improve vision that has declined in aged individuals using simple brief exposures to light wavelengths that recharge the energy system that has declined in the retina cells, rather like re-charging a battery.

Morning exposure to deep red light improves declining eyesight — ScienceDaily
Extract: Professor Jeffery said: “Using a simple LED device once a week, recharges the energy system that has declined in the retina cells, rather like re-charging a battery.
“And morning exposure is absolutely key to achieving improvements in declining vision: as we have previously seen in flies, mitochondria have shifting work patterns and do not respond in the same way to light in the afternoon — this study confirms this.”
For this study the light energy emitted by the LED torch was just 8mW/cm2, rather than 40mW/cm2, which they had previously used. This has the effect of dimming the light but does not affect the wavelength. While both energy levels are perfectly safe for the human eye, reducing the energy further is an additional benefit.

Red Light and the Sleep Quality and Endurance Performance of Chinese Female Basketball Players
Red Light and the Sleep Quality and Endurance Performance of Chinese Female Basketball Players – PMC (nih.gov)
Conclusions: Our study confirmed the effectiveness of body irradiation with red light in improving the quality of sleep of elite female basketball players and offered a nonpharmacologic and noninvasive therapy to prevent sleep disorders after training.

skin-homing T- cells in human subjects.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2539004/
Extract: LED phototherapy at 630nm increases local levels of skin-homing T- cells in human subjects.

Effect of helium-neon and infrared laser irradiation on wound healing in rabbits
https://www.ncbi.nlm.nih.gov/pubmed/2927230
Extract: Thus, laser irradiation at 632.8 nm and 904 nm alone or in combination increased tensile strength during wound healing and may have released tissue factors into the systemic circulation that increased tensile strength on the opposite side as well.

Light-Emitting Diodes (LEDs) in Dermatology (mdedge.com)
Dermatology
Extract: obtain excellent outcomes in a variety of skin conditions. Safer than sunlight, this new low level light therapy allows for the treatment of patients without pain, downtime or side effects
Extract: Rapidly emerging areas in light-based therapy include the treatment of cellulite and hair loss. Both conditions are very prevalent for which acceptable treatment options are lacking

Use of laser light to treat certain lesions in standardbreds
Study into race times after Red Light Therapy treatment
https://www.ncbi.nlm.nih.gov/pubmed/6727856
Extract: The final and last-quarter race times and racing classes for a group of Standardbreds were analyzed before and after infrared laser light treatment. These horses had either check ligament injuries, plantar desmitis or pharyngeal lymphoid hyperplasia. A 904-nm infrared laser was used to treat check ligaments at 146 Hz for 26 sec/cm2 of affected area, acute plantar desmitis at 73 Hz and chronic plantar desmitis at 292 Hz for 26 sec/cm2 of affected area, and pharyngeal lymphoid hyperplasia at 146 Hz for 5 minutes. Of 35 horses treated for check ligament injuries, 80% had similar or faster final race times, 68.6% had similar or faster last-quarter times, and 68.6% raced in similar or higher classes after treatment. Of 8 horses treated for plantar desmitis, 87.5% had similar or faster final and last-quarter times, and raced in similar or higher classes after treatment. Of 30 horses treated for pharyngeal lymphoid hyperplasia, 80% had similar or faster final race times, 90% had similar or faster last-quarter times, and 70% raced in similar or higher classes after treatment.

Effect of NASA light-emitting diode irradiation on wound healing.
https://www.ncbi.nlm.nih.gov/pubmed/11776448
Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. Wound size decreased up to 36% in conjunction with HBO in ischemic rat models. LED produced improvement of greater than 40% in musculoskeletal training injuries in Navy SEAL team members, and decreased wound healing time in crew members aboard a U.S. Naval submarine. LED produced a 47% reduction in pain of children suffering from oral mucositis.
Conclusion: We believe that the use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/illness level of activity. This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program.

NEAR-INFRARED LIGHT THERAPY RESEARCH

NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea (marquette.edu)
NASA Research – Medical applications
Extract: Muscle and bone atrophy are well documented in astronauts, and various minor injuries occurring in space have been reported not to heal until landing on Earth. An LED blanket device may be used for the prevention of bone and muscle atrophy in astronauts. The depth of near-infrared light penetration into human tissue has been measured spectroscopically (Chance, et al., 1988). Spectra taken from the wrist flexor muscles in the forearm and muscles in the calf of the leg demonstrate that most of the light photons at wavelengths between 630-800 nm travel 23 cm through the surface tissue and muscle between input and exit at the photon detector. The light is absorbed by mitochondria where it stimulates energy metabolism in muscle and bone, as well as skin and subcutaneous tissue.

Clinical and experimental applications of NIR-LED photobiomodulation
Dr Harry T Whelan. Professor of Neurology, Pediatrics, and Hyperbaric Medicine
http://www.ncbi.nlm.nih.gov/pubmed/16706690
Extract: Positive effects of NIR-light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production.
Extract: The experimental results demonstrate that NIR-LED light treatment stimulates mitochondrial oxidative metabolism in vitro, and accelerates cell and tissue repair in vivo. NIR-LED light represents a novel, noninvasive, therapeutic intervention for the treatment of numerous diseases linked to mitochondrial dysfunction.

Effect of NASA light-emitting diode irradiation on wound healing
http://www.ncbi.nlm.nih.gov/pubmed/11776448
Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. Wound size decreased up to 36% in conjunction with HBO in ischemic rat models. LED produced improvement of greater than 40% in musculoskeletal training injuries in Navy SEAL team members, and decreased wound healing time in crew members aboard a U.S. Naval submarine. LED produced a 47% reduction in pain of children suffering from oral mucositis.

Photobiomodulation with 670 nm light increased phagocytosis in human retinal pigment epithelial cells
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544713/
Conclusions: These findings indicate that near-infrared light photobiomodulation (670 nm) may be a noninvasive, inexpensive, and easy adjunctive therapy to help inhibit the development of ocular diseases induced by the activation of phagocytosis

Infrared therapy for chronic low back pain: A randomied, controlled trial
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2539004/
Conclusion: The IR therapy unit used was demonstrated to be effective in reducing chronic low back pain, and no adverse effects were observed.

Light-emitting diode phototherapy at 630 +/- 3 nm increases local levels of skin-homing T-cells in human subjects
http://www.ncbi.nlm.nih.gov/pubmed/16641531
Conclusion: Visible red LED irradiation appears to activate the skin-homing immune system

Evidence of changes in sural nerve conduction mediated by light emitting diode irradiation
http://www.ncbi.nlm.nih.gov/pubmed/15895289
Extract: Based on these results, it can be concluded that LED irradiation, applied to intact skin at the described irradiation parameters, produces an immediate and localized effect upon conduction characteristics in underlying nerves. Therefore, the outcome of this in vivo experiment yields a potential explanation for pain relief induced by LED.

Mechanisms of Low Light Therapy
http://www.photobiology.info/Hamblin.html
Extract: The use of low levels of visible or near-infrared (NIR) light for reducing pain, inflammation and edema, promoting healing of wounds, deeper tissues and nerves, and preventing tissue damage has been known for almost forty years since the invention of lasers.
Extract: Mitochondria are thought to be a likely site for the initial effects of light, leading to increased ATP production, modulation of reactive oxygen species, and induction of transcription factors. These effects in turn lead to increased cell proliferation and migration (particularly by fibroblasts), modulation in levels of cytokines, growth factors and inflammatory mediators, and increased tissue oxygenation.

Role of Low-Level Laser Therapy in Neurorehabilitation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065857/
Extract: This review will cover the mechanisms of LLLT that operate both on a cellular and a tissue level. Mitochondria are thought to be the principal photoreceptors, and increased adenosine triphosphate, reactive oxygen species, intracellular calcium, and release of nitric oxide are the initial events. Activation of transcription factors then leads to expression of many protective, anti-apoptotic, anti-oxidant, and pro-proliferation gene products. Animal studies and human clinical trials of LLLT for indications with relevance to neurology, such as stroke, traumatic brain injury, degenerative brain disease, spinal cord injury, and peripheral nerve regeneration, will be covered.
Extract Conclusion: We believe that the high benefit:risk ratio of LLLT should be better appreciated by medical professionals in the rehabilitation and physical medicine specialties.

Effects of low-power light therapy on wound healing: LASER x LED
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148276/
Extract Conclusion: The biological effects promoted by these therapeutic resources are similar and are related to the decrease in inflammatory cells, increased fibroblast proliferation, angiogenesis stimulation, formation of granulation tissue and increased collagen synthesis. In addition to these effects, the irradiation parameters are also similar between LED and LASER.

Is light-emitting diode phototherapy (LED-LLLT) really effective?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799034/
Extract: Among the clinical applications, non-healing wounds can be healed through restoring the collagenesis/collagenase imbalance in such examples, and ‘normal’ wounds heal faster and better. Pain, including postoperative pain, postoperative edema and many types of inflammation can be significantly reduced.

The Use of NASA Light-Emitting Diode Near-Infrared Technology for Biostimulation
https://ntrs.nasa.gov/search.jsp?R=20030001599
Extract: NASA LEDs stimulate the basic energy processes in the mitochondria (energy compartments) of each cell, particularly when near-infrared light is used to activate the color sensitive chemicals (chromophores, cytochrome systems) inside.

Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796659/
Conclusion: This small feasibility study suggests that NIR-PBM may have utility for the treatment of depression and other psychiatric disorders and that double blind randomized placebo-controlled trials are indicated.

Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627142/
Conclusion: This is the first report of high-powered NILT showing efficacy for depression. Multi-Watt NILT showed far greater efficacy and persistent benefit compared to low-power

Effect of near-infrared light on in vitro cellular ATP production of osteoblasts and fibroblasts and on fracture healing with intramedullary fixation.
https://www.ncbi.nlm.nih.gov/pubmed/27857496
Conclusion: The study demonstrated an immediate increase in ATP production in vitro and an initial acceleration of callus formation in the fracture healing process, in the presence of NIR

Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/
Conclusion: A growing body of clinical evidence is showing that applying 830 nm LED-LLLT as soon as possible post-procedure, both invasive and noninvasive, successfully hastens the resolution of sequelae associated with patient downtime in addition to significantly speeding up frank wound healing. This article reviews that evidence, and attempts to show that 830 nm LED-LLLT delivers swift resolution of postoperative sequelae, minimizes downtime and enhances patient satisfaction.

Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651919/
Extract:  Our findings highlight the novel insight that FIR preconditioning significantly promotes BMSC proliferation, migration, cell survival, and recovery against H2O2. In general, FIR radiation transfers energy to the human body and manifests a wide variety of biological effects, including improvement of ischemic lesions.
Extract:  For example, red (630 nm) and near infrared (850 nm) light-emitting diodes enhance the migration of MSCs derived from rat bone marrow11–13. Other studies have demonstrated that a diode (Ga-As) laser of wavelength 804 nm promots the proliferation of BMSCs and cardiac stem cells14–16. Interestingly, preconditioning using this wavelength has exhibited a cardioprotective effect on myocardial ischemia/reperfusion (I/R) injury in vivo 16. Another study has suggested that postconditioning with FIR increases heme oxygenase-1 expression and protects against I/R injury in rat testes17.
Extract:  In the case of acute kidney injury, the overexpression of CXCR4 has been shown to enhance the repair ability of BMSCs, increasing the homing of BMSCs and increasing the release of cytokines22. In a case of skin injury repair, CXCR4 overexpression in BMSCs promoted wound healing in a SDF-1-expression-dependent manner23.

NASA Light Technology Successfully Reduces Cancer Patients Painful Side Effects from Radiation and Chemotherapy
https://www.nasa.gov/topics/nasalife/features/heals.html
Extract: LEDs are light sources releasing energy in the form of photons. They release long wavelengths of light that stimulate cells to aid in healing. HEALS technology allows LED chips to function at their maximum irradiancy without emitting heat. NASA is interested in using HEALS technology for medical uses to improve healing in space and for long-term human spaceflight.

US Department of Veteran Affairs – Research & Development – Can Light Therapy help the brain?
https://www.research.va.gov/currents/spring2015/spring2015-7.cfm
Extract: She believes light therapy can be a valuable adjunct to standard cognitive rehabilitation, which typically involves “exercising” the brain in various ways to take advantage of brain plasticity and forge new neural networks.
“The light-emitting diodes add something beyond what’s currently available with cognitive rehabilitation therapy,” says Naeser. “That’s a very important therapy, but patients can go only so far with it. And in fact, most of the traumatic brain injury and PTSD cases that we’ve helped so far with LEDs on the head have been through cognitive rehabilitation therapy. These people still showed additional progress after the LED treatments. It’s likely a combination of both methods would produce the best results.”

SHORT-TERM EFFICACY OF LOW-LEVEL LASER THERAPY IN PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMIZED PLACEBO-CONTROLLED, DOUBLE-BLIND CLINICAL TRIAL – PubMed (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/27027049/
Results: A significant improvement in pain and function was found in all the assessments applied to the laser group. On comparing the laser group with the placebo group, significant differences were found in the VNS-resting and Lequesne evaluations.
Conclusion: Treatment with LLLT improves pain and function over the short term in patients with knee osteoarthritis.

Validated Scientific Accredited Data

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